Ultra-High Pressure Liquid Chromatography Quadrupole Time of Flight Mass Spectrometer

SOURCES SOUGHT NOTICE Notice ID Number: NB682050-26-017161 Title: Ultra-High Pressure Liquid Chromatography Quadrupole Time of Flight Mass Spectrometer Department of Commerce Advanced Acquisition Planning Entry Number: NA PURPOSE The purpose of this sources sought notice is to conduct market research and identify potential sources of commercial products/services that satisfy the Government’s anticipated needs. BACKGROUND The Surface and Trace Chemical Analysis Group (STCAG) of the Materials Measurement Science Division (MMSD) of the Materials Measurement Laboratory (MML) has significant research efforts in the fields of analytical chemistry and mass spectrometry, targeting the forensic science, public health, and homeland security communities. These efforts revolve around the chemical classification, identification, and characterization of relevant compounds, including drugs, metabolites, and explosives. A major component of these efforts is the Rapid Drug Analysis and Research (RaDAR) program. The RaDAR program provides comprehensive, near real-time analysis of drug residues collected from public safety and public health entities across the U.S. Over the last 24 months the RaDAR program has grown significantly and to accommodate this growth there is a need to increase the qualitative testing capacity of the program. Existing testing is currently completed on two platforms – direct analysis in real time, time-of-flight mass spectrometry (DART-MS) and liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF). We are looking to expand our LC-QTOF capacity as this platform requires less analyst time and around-the-clock analysis capabilities. To ensure all methods, spectral libraries, and data processing tools that have been previously developed can be directly translated to a new system, we are seeking to procure an LC-QTOF instrument that is identical to the one currently in use for testing in our laboratory. The system is a Bruker Elute ultra-high pressure liquid chromatography (UHPLC) coupled with a Bruker Compact quadrupole time of flight mass (QTOF) spectrometer. All necessary data analysis software and a computer needs to also be provided. This procurement is a brand name or equal to purchase a) Bruker Elute ultra-high pressure liquid chromatography (UHPLC) coupled with a Bruker Compact quadrupole time of flight mass (QTOF) spectrometry system or EQUAL that meets or exceeds the following salient requirements: General Requirements The system shall include a benchtop QTOF mass spectrometer and an UHPLC system. The system shall include a PC-based data system/instrument controller including operating system, instrument control/data acquisition/data analysis software, and monitor. The system shall include an electrospray ionization (ESI) source and have the ability to interface with a direct analysis in real time (DART) source or an atmospheric pressure photoionization (APPI) source. The benchtop system, including UHPLC and QTOF, shall weigh less than 600 pounds. The system shall fit on a standard laboratory bench (30 inches deep), with the inlet of the mass spectrometer facing outwards towards the operator. The system shall be no higher than 50 inches tall. System The ionization sources shall be able to be changed without breaking the vacuum of the mass spectrometer. The ESI probe shall be capable of liquid flow rates of 1 µL/min to 1 mL/min. The ESI source shall have a vacuum insulated probe and an active exhaust. The transfer ion optics shall be designed for high stability and ion transmission efficiency and shall include an ion funnel, stacked ring ion guide, or similar mechanism to provide efficient ion delivery to the mass analyzer. The QTOF system shall have a minimum mass range of m/z 20-4,000. The QTOF system shall have a resolving power of at least 30,000 full width half max (FWHM) that is independent of scan frequency or mass range and can be used in full scan or tandem (MS/MS) data acquisition. The...